RHPS4,390362-78-4

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RHPS4

CAS No. : 390362-78-4

MCE 国际站：RHPS4

产品活性：RHPS4 是有效的端粒酶 (telomerase) 抑制剂 (IC₅₀ = 0.33 μM)。RHPS4 是 DNA 损伤的诱导剂。

研究领域：Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：Telomerase  |  Apoptosis

In Vitro: RHPS4 could sensitize tumor cells to anticancer agents that act via disparate mechanisms.
?RHPS4 (0.5-1 μM, 15 days) induces a senescent-like growth arrest in MCF-7 cells.
?RHPS4 (1 μM, 4 days) induces phosphorylation of H2AX in transformed and tumor cells.

In Vivo: RHPS4 (15 mg/kg, iv, 15 days) treatment produces a marked inhibition of tumor weight (tumor weight inhibition [TWI] about 80%; P < 0.001) in a very short time, and this effect persists for at least 30 days. A complete tumor response is observed in 80% of mice, and 40% are cured.
?In all the other tumor xenografts, RHPS4 treatment produces about 50% (P < 0.001) TWI at the nadir of the effect and, more important, results in a delay of tumor growth of about 15 (M14 and PC3) and 10 (HT29 and H460) days.

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