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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
AJM300
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
401905-67-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2079.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥850.0 |
| 规格： | 5 mg | 产品价格： | ￥1890.0 |
| 规格： | 10 mg | 产品价格： | ￥3024.0 |
| 规格： | 25 mg | 产品价格： | ￥5135.0 |
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Carotegrast methyl
CAS No. : 401905-67-7
MCE 国际站：Carotegrast methyl
产品活性：Carotegrast methyl (AJM300) 是一种口服有效和选择性 α4 整联蛋白 (α4 integrin) 拮抗剂。HCA2969 是 Carotegrast methyl 的活性代谢产物，是一种特异的双重 α4β1/α4β7 整联蛋白拮抗剂。Carotegrast methyl 可预防小鼠结肠炎。
研究领域：Cytoskeleton
作用靶点：Integrin
In Vitro: HCA2969 inhibits human α4β1 integrin (KD=0.32 nM; IC50=5.8 nM), human α4β7 integrin (KD=0.46 nM; IC50=1.4 nM) and mouse α4β7 integrin (KD=0.2 nM; IC50=26 nM) in Jurkat, RPMI-8866 and TK-1 cell lines.
In Vivo: Carotegrast methyl (AJM300; oral; 0.03-1%; for 15 days) prevents the development of colitis induced by transfer of IL-10 deficient CD4+ T cells in mice.
?Carotegrast methyl (oral; 0.3, 3, 30, or 30 mg/kg; a single oral) inhibits Lymphocyte homing to Peyer's patches and increases peripheral lymphocyte counts in a dose-dependent manner in BALB/c mice (8 weeks of age, female).
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文献和实验.9 50 13.191 4-Methylcyclopetene(4-甲基环戊烯) 65.66 51 13.291 3-Hexene(3-己烯) 66.4~67.1 52 13.412 2-Hexene(2-己烯) 68.9~67.9 53 13.586 3-Methyl-2-pentene(3-甲基-2-戊烯) 67.7~70.4 54 13.860 Methylcyclopetane(甲基环戊烷) 71.8 R5 55 14.152 3-Methyl
(DNA) Ladder in hydroxypropyl methyl cellulose (HPMC) concentration ran ging from 1.25 g/L to 16.06 g/L. The friction force mobility μf is used to expr ess the friction force that DNA will encounter in capillary electrophoresis. Our results indicate
Crystallization of Kinesin Family Motor Proteins
temperature11 mg/ml protein 10 mM HEPES pH 7.5, 150 mM NaCl, 1 mM DTT, 1 mM MgCl2, 0.2 mM NaN3, 2 mM ADP combined 1:1 with 22% methyl ether PEG 2000, 100 mM NaCl, 2% ethylene glycol, 50 mM HEPES pH 7.0Gulick et al., 1998Ncd 281-700Sitting drop 4°C20 mg/ml
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