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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1087784-71-1
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 1 mg | 产品价格： | ￥120.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥283.0 |
| 规格： | 10 mg | 产品价格： | ￥448.0 |
| 规格： | 25 mg | 产品价格： | ￥915.0 |
| 规格： | 50 mg | 产品价格： | ￥1338.0 |
| 规格： | 100 mg | 产品价格： | ￥2013.0 |
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Metallo β-lactamase ligand 1
CAS No. : 1087784-71-1
MCE 国际站：Metallo β-lactamase ligand 1
产品活性：Metallo-beta-lactamase ligand 1 是一种有效的 B 类 β-lactamase 抑制剂，详细信息请参考专利文献 WO2019221122A1 中的化合物 A。
研究领域：Anti-infection
作用靶点：Bacterial
In Vitro: One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent.
The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells.
In Vivo: After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate.
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文献和实验of a tetracysteine (4C) hexapeptide-encoding sequence into the coding sequence of the antibiotic hydrolyzing enzyme TEM-1 β-lactamase. This procedure could also be applied to insert different DNA sequences or to replace, or delete, existing fragments in a given gene
Theoretical Aspects of the Quantitative Characterization of Ligand Binding
dependences of the binding function ( r ) upon free ligand concentration ( C S ) for various types of acceptor‐ligand interaction. Rectangular hyperbolic dependence (—) for an acceptor with two equivalent and independent sites ( K AS = K 1 = K 2 = K 3 = K
Quantitative Determination of Protein Stability and Ligand Binding by Pulse Proteolysis
also can be used to determine the affinity of a ligand to its protein target by monitoring the change in protein stability upon ligand binding. The Basic Protocol describes the detailed procedure for determining protein stability using pulse proteolysis. For pulse
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