JNJ-5207852,1782228-76-5

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JNJ-5207852 dihydrochloride

CAS No. : 1782228-76-5

MCE 国际站：JNJ-5207852 dihydrochloride

产品活性：JNJ-5207852 dihydrochloride 是组胺 H₃ 受体有选择性的有效拮抗剂，其对大鼠和人类 H₃ 受体的 pK_i 值分别为 8.9，9.24。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vivo: JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H₃ receptor knockout mice. The wake promoting effects of this H₃ receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels.

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