Vodobatinib,1388803-90-4

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Vodobatinib

CAS No. : 1388803-90-4

MCE 国际站：Vodobatinib

产品活性：Vodobatinib (K0706) 是一种有效的第三代，且具有口服活性的 Bcr-Abl1 酪氨酸激酶抑制剂，IC₅₀ 为 7 nM。Vodobatinib 对大多数 BCR-ABL1 点突变体具有活性，对 BCR-ABL1T315I 无活性。 Vodobatinib 可用于慢性粒细胞白血病 (CML) 研究。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：Bcr-Abl

In Vitro: In Ba/F3 cells expressing BCR-ABL1, BCR-ABL1_L248V, BCR-ABL1_Y253H, or BCR-ABL1_E255V, Vodobatinib (K0706; 0-2000 nM) treatment shows potent inhibition of BCR-ABL1 tyrosine autophosphorylation.

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