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- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
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10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2235.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥870.0 |
| 规格： | 5 mg | 产品价格： | ￥2225.0 |
| 规格： | 10 mg | 产品价格： | ￥3350.0 |
| 规格： | 25 mg | 产品价格： | ￥5150.0 |
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BTK inhibitor 17
CAS No. : 1858206-76-4
MCE 国际站：BTK inhibitor 17
产品活性：BTK inhibitor 17 是一种有效的具有口服活性不可逆 BTK 抑制剂，IC50 为 2.1 nM。BTK inhibitor 17 可用于类风湿关节炎的研究。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：Btk
In Vitro: BTK inhibitor 17 (compound 8) could covalently bind to Cys481 and formed an HB network with hinge key residues Met477, Glu475, and gatekeeper Thr474.
In Vivo: BTK inhibitor 17 (compound 8; 3-10 mg/kg; oral gavage; daily; for 28 days) treatment inhibits the significant progression of the disease and exhibits a clear dose-dependent reduction per paw clinical scores, and no significant body weight loss is observed for all different dosages.
BTK inhibitor 17 (compound 8) shows >95% plasma protein binding across three species of human, rat, and mouse. After an intravenous injection, the half-life (rat, 0.32 h; mice, 0.42 h), clearance (rat, 54.6 mL/min/kg; mice, 31.3 mL/min/kg), volume of distribution (rat, 1.55 L/kg; mice, 0.82 L/kg), and AUC exposure (rat, 604 ng.h/mL; mice, 576 ng.h/mL) are observed in two species. After oral administration, BTK inhibitor 17 exhibits higher Cmax (rat, 466 ng/mL; mice, 252 ng/mL) and plasma exposure (rat, 642 ng.h/mL; mice, 128 ng.h/mL) with a favorable oral bioavailability (rat, 23.7%; mice, 11.2%).
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文献和实验Culturing Chick Embryonic Myoblasts/Myotubes and Fibroblasts
nitex filter. Gently apply negative pressure with a 6 ml plastic syringe. Hold the filter at an angle so that filtrate can flow along the side of the tube. Keep the collecting tube on ice. 17. Add 2 ml cold medium to settled pieces. The medium
and IFN-beta induce synthesis of TNF-{alpha}, only IFN-beta requires this factor for stimulation of miR-155 accumulation. Inhibitor studies demonstrated that the increase in miR-155 stimulated by either pathway requires JNK activity, leading
【分享】MIRNA(microRNA)检测实验流程(加polyA法) (2011
hsa-miR-26a 75 脑 22.66 16 17 hsmq-0047_01 hsa-miR-29b 76 脑 26.72 17 18 hsmq-0048_01 hsa-miR-30c 76 脑 26.54 18 19 hsmq-0049_01 hsa-miR-9 76 脑 23.11 19 20 hsmq-0050_01 hsa-miR-99b 75 脑 27.06 20 21
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