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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥5342.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1450.0 |
| 规格： | 5 mg | 产品价格： | ￥3300.0 |
| 规格： | 10 mg | 产品价格： | ￥4950.0 |
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DS-1205b free base
CAS No. : 1855860-24-0
MCE 国际站：DS-1205b free base
产品活性：DS-1205b free base 是一种有效和选择性的 AXL 激酶抑制剂，IC50 值为 1.3 nM。DS-1205b free base 还可以抑制 MER，MET 和 TRKA，IC50 值分别为 63、104 和 407 nM。 DS-1205b free base 可以抑制细胞迁移和肿瘤生长。
研究领域：Protein Tyrosine Kinase/RTK | Neuronal Signaling
作用靶点：TAM Receptor | c-Met/HGFR | Trk Receptor
In Vitro: DS-1205b (0.3-33 μM; 2-24 h) inhibits hGAS6-induced migration in NIH3T3-AXL cells (EC50=2.7 nM).
DS-1205b (1-10000 μM; 2-24 h) significantly inhibits the phosphorylation of AXL in NIH3T3-AXL cells. DS-1205b decreases NIH3T3 cell proliferation but not obviously inhibits growth (GI50>10,000 nM).
In Vivo: DS-1205b (3.1-50 mg/kg; p.o. bid for 5 d) exhibits pAXL inhibition mediated antitumor effects in mice.
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文献和实验光度计测量的转换: 双链DNA (ds DNA)：A260 = OD260 = 1 相当于50 µg/ml溶液 单链DNA(ss DNA)：A260 = OD260 = 1相当于33 µg/ml溶液 RNA：A260 = OD260 = 1相当于40 µg/ml溶液 参考文献：Freifelder, D., Physical Biochemistry: Applications to Biochemistry & Molecular Biology, W.H. Freeman
Protocol for mRNA amplification--RT-PCR实验过程
C for 5min to digest mRNA, 94C for 2min to denature, 65C for 1min for specific priming and 75C for 30min for extension. Stop reaction with 7.5ul 1M NaOH. Incubate at 65C for 10min to inactivate enzyme. DS cDNA cleanup: Add to PCR Tube
佚名 1．徐丰彦，张镜如主编.人体生理学.北京：人民卫生出版社，1989 2．韩济生主编.神经科学纲要.北京：北京医科大学、中国协和医科大学联合出版社1993 3．潘家右，伍嘉宁. NO：中枢神经中一个新的重要信使物质.生理科学进展1993；24：293-297 4．包雅琳，郭 恒怡.M受体亚型研究的新进展。生理科学进展 1992；23
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