IDO1-IN-7,2351199-98-7

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IDO1-IN-7

CAS No. : 2351199-98-7

MCE 国际站：IDO1-IN-7

产品活性：IDO1-IN-7 是一种高效、选择性的 IDO1 抑制剂，在细胞中对 IDO1 作用的 IC₅₀ 值为 6.1 nM。 IDO1-IN-7 具有免疫调节作用，用于癌症的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Indoleamine 2,3-Dioxygenase (IDO)

In Vitro: IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC₅₀of 330 nM.
IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity.
IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC₅₀=14,000 nM).

In Vivo: IDO1-IN-7 (10 mg/kg; p.o.) shows C_max=10.0 µM, AUC_{0-8 h}=27.1 µM*h, t_1/2=1.4 h in mouse.

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