Ruthenium red钌红,11103-72-3

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Ruthenium red

CAS No. : 11103-72-3

MCE 国际站：Ruthenium red

产品活性：Ruthenium red (Ammoniated ruthenium oxychloride) 是一种聚阳离子染料，广泛用于电子显微镜 (EM) 下细胞、组织和营养细菌的观察。Ruthenium red 能与磷脂和脂肪酸反应强烈，并与酸性粘多糖结合。Ruthenium red 还是一种 L 型钙电流 (I_Ca) 阻断剂。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: Ruthenium red staining of intracellular organelles and structures seemed to depend on the time of exposure to this agent, as well on the concentration used.
Ruthenium red efficiently blocks the L-type calcium current in a dose-dependent manner in in guinea-pig isolated ventricular heart cells, with EC₅₀ of 0.8 μM.
Ruthenium red (10 μM) blocks the sarcoplasmic Ca²⁺ release channels or the mitochondrial Ca²⁺ uptake, and blocks 26.7 % of the sodium current, and slows its inactivation time-course in guinea-pig isolated ventricular heart cells.

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