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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
-20°C, stored under nitrogen
- 英文名：
N-Octanoyl-D-erythro-sphingosine
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
74713-59-0
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1045.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥950.0 |
| 规格： | 10 mg | 产品价格： | ￥1650.0 |
| 规格： | 25 mg | 产品价格： | ￥3600.0 |
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C8-Ceramide
CAS No. : 74713-59-0
MCE 国际站：C8-Ceramide
产品活性：C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性，能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide 在体外能轻微地诱导 PKC 活化。
研究领域：Apoptosis | TGF-beta/Smad | Epigenetics | Autophagy
作用靶点：Apoptosis | PKC | Autophagy
In Vitro: C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes.
C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells.
C8-ceramide may increase the endogenous ROS level (10-30 µM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 µM; 24 hours), and consequently triggering the apoptosis (10-50 µM; 48 hours) of NSCLC H1299 cells.
In Vivo: C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8+ and CD4+ T cell responses to viral infections in virus infected mice.
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