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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human Macrophage migration inhibitory factor (MIF) (Active)
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
20μg
英文名称:
Recombinant Human Macrophage migration inhibitory factor (MIF) (Active)品名简称:
Recombinant Human MIF protein (Active)货号:
CSB-MP013826HU规格:
20μg价格:
828LC-MS/Western Blot:
/SDS-PAGE:
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.纯度:
Greater than 85% as determined by SDS-PAGE.内毒素:
Less than 1.0 EU/μg as determined by LAL method.生物活性:
①Measured by its binding ability in a functional ELISA. Immobilized MIF at 2 μg/ml can bind Anti- MIF Rabbit Monoclonal Antibody(CSB-RA146975A0HU), the EC50 is 49.61-69.45 ng/ml.基因名:
MIFUniprot No.:
P14174别名:
(MIF)(Glycosylation-inhibiting factor)(GIF)(L-dopachrome isomerase)(L-dopachrome tautomerase)(Phenylpyruvate tautomerase)种属:
Homo sapiens (Human)蛋白长度:
Full Length of Mature Protein来源:
Mammalian cell分子量:
41.3 kDa表达区域:
2-115aa氨基酸序列:
PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA蛋白标签:
C-terminal hFc1-tagged产品提供形式:
Lyophilized powder缓冲液:
Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
3-7 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.功能2:
/文献:
/研究领域:
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文献和实验. 61, 83–91. Yu, S.-M., Hung, L.-M., Lin, C.-C., 1997. cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway. Circulation 95, 1269–1277. Yuan, R., Lin, Y
丘脑下部-脑下垂体神经分泌系统 hypotha-lamohypophysial eurosecretory system
因子( releasing factorRF)或抑制因子( inhibiting factor IF)。在 RF中存在着与促黄体(生成)激素( LH)、促卵泡激素( FSH),促甲状腺激素( TSH),促肾上腺皮质激素( corticotropin)相对应的 LRF、 FRF、 TRF、 CRF,在 IF中则存在着与催乳激素相对应的 PIF。还有与生长激素( GH或 somatotropin)相对应的 GRF(或 SRF)和相反的所谓 GIF也存在。关于促黑(素细胞)激素( MSH)也有 MIF,实际上可能还存在
复发,无法根治,给患者带来了极大的心理压力,严重影响患者的生存质量。角质形成细胞中丝苏氨酸蛋白磷酸酶 -6(PP6)的表达失衡是银屑病炎症的主要原因,平衡角质形成细胞中 PP6 的表达有望成为治疗银屑病的全新策略。 2022 年 12 月 19 日上海交通大学医学院的王宏林教授和他的团队在nature communications上发表了题为「Targeting the transcription factor Hes1 by L-menthol restores protein
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