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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 保质期:
12个月
- 英文名:
Recombinant Human ICOS ligand (ICOSLG), partial (Active)
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
10ug/20ug/50ug/100ug/200ug/500ug/1mg
| 规格: | 10ug | 产品价格: | ¥69.0 |
|---|---|---|---|
| 规格: | 20ug | 产品价格: | ¥139.0 |
| 规格: | 50ug | 产品价格: | ¥209.0 |
| 规格: | 100ug | 产品价格: | ¥349.0 |
| 规格: | 200ug | 产品价格: | ¥419.0 |
| 规格: | 500ug | 产品价格: | ¥559.0 |
| 规格: | 1mg | 产品价格: | ¥699.0 |
Research Areas
CancerUniprot ID
O75144Gene Names
ICOSLGAlternative Name(s)
B7 homolog 2 (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1)Lead Time
3-7 business daysOrganism
Homo sapiens (Human)Source
Mammalian cellExpression Region
19-258aaProtein Length
PartialTag Info
C-terminal 6xHis-taggedTarget Protein Sequence
DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSMW
28.9 kDaPurity
Greater than 95% as determined by SDS-PAGE.Form
Lyophilized powder.If the size you ordered does not have lyophilized powder in stock, we will provide it in liquid formBuffer
Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验B7-H Abnormalities in Melanoma and Clinical Relevance
as well as altered expression of co-stimulatory and coinhibitory signals. Recently, an important role of B7-H1 and B7-H4 in the immune escape of melanoma has been described. High mRNA and/or protein expression levels of these coinhibitory molecules were detected
B7 家族 白细胞分化抗原及其功能 B7―1和B7-2 B7―1和B7―2分别称CD80和CD86,属B7家族成员。胞膜外区结构属IgSF成员,各有1个V样区和C2区,两者在氨基酸水平上有25%同源性。CD80胞质区较短,富含精氨酸,有1个RRES序列,为钙调蛋白依赖的磷酸化位点;CD86胞质区含有3个PKC磷酸化位点。 在活化的T细胞、B细胞和单核细胞表达水平明显增加。IL-4和TNF-7分别上调B细胞和单核细胞CD86表达
1. T、B细胞相互作用的过程T细胞为Th2亚群,而B细胞既是Th细胞辅助的对象,又是T细胞活化的APC。这一相互合作包括一系列过程:①抗原以其B表位(绿色)与BCR结合传递B细胞活化的第一信号,使其C1340与细胞因子受体的表达增加,并使B细胞加工提呈抗原和表达少量D7分子;②B细胞作为APC将带有T表位(红色)的抗原肽提呈给CD4T细胞,供T细胞识别;③初步活化的T细胞表达CD40L等,与B细胞表面CD40结合成为B细胞活化的第二信号;④活化B细胞表达B7分子与CD28结合为T细胞提供第二
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