CTLA4/CTLA4蛋白Recombinant Guine

纯度：

Greater than 90% as determined by SDS-PAGE.

基因名：

CTLA4

Uniprot No.：

H0VUB1

别名：

Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4

种属：

Cavia porcellus (Guinea pig)

蛋白长度：

Partial

来源：

Yeast

分子量：

14.1 kDa

表达区域：

37-161aa

氨基酸序列：

AMHVAQPAVVLASSRGVASFECEYASSHNANEVRVTVLQQVASRTTEICAATYTVERELAFPEDSACAGTSSGTRVNLTIQGLRAADTGLYICKVELMYPPPYFVGTGNGTQIYVIDPEPCPDSD

蛋白标签：

C-terminal 6xHis-tagged

产品提供形式：

Liquid

缓冲液：

0.2 μm filtered 1xPBS, pH 7.4

货期：

5-10 business days

注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

功能：

Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

内毒素：

Less than 1.0 EU/µg as determined by LAL method.

SDS-PAGE:

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LC-MS Image Description/Western Blot:

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Product types:

Active Protein & In Stock Protein

Biological_Activity:

Measured by its binding ability in a functional ELISA. Immobilized Mouse B7-1-Fc at 5 μg/ml can bind Cavia porcellus CTLA-4-His, the ED50 of Recombinant Cavia porcellus CTLA-4-His is 4.29 ng/ml.

Research Areas:

Immunology

Reconstitution:

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Reference:

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Function:

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