Human High Density Lipoprotein

产品名称：【HDL】人高密度脂蛋白-Human High Density Lipoprotein

产品货号：pro-559-E

产品规格：1

应用类型： Human High Density Lipoprotein （HDL） produced in Human plasma.

保存建议：【HDL】人高密度脂蛋白-Human High Density LipoproteinHuman HDL although stable at 4℃ for 1 week， should be stored desiccated below -15℃. （short term i.e. < 3 months） and below -70℃ for long term.

背景资料：HDL is a complex of lipids and proteins in approximately equal amounts that functions as a transporter of cholesterol in the blood. HDL is the smallest of the lipoprotein particles； it’s the densest because it contains the highest proportion of protein. The liver synthesizes these lipoproteins as complexes of apolipoproteins and phospholipid， which bear a resemblance to cholesterol-free flattened spherical lipoprotein particles. They pick up cholesterol； carry it internally， from cells by interaction with the ATP Binding Cassette Transporter A1. Lecithin-cholesterol acyltransferase （plasma enzyme） converts the free cholesterol into cholesteryl ester （a more hydrophobic form of cholesterol） which is then sequestered into the core of the lipoprotein particle ultimately making the newly synthesized HDL spherical. They increase in size as they pass through the bloodstream and integrate more cholesterol and phospholipid molecules from cells and other lipoproteins， for instance by the interaction with the ABCG1 transporter and the phospholipid transport protein. HDL transports their cholesterol generally to the liver or steroidogenic organs such as adrenals， ovary and testes by direct and indirect pathways. The release of HDL cholesterol to adrenals， ovaries and testes is important for the synthesis of steroid hormones. Since the triglycerides are not stable in HDL， they’re degraded by hepatic lipase in order that finally small HDL particles are left which resume the uptake of cholesterol from cells. The cholesterol supplied to the liver is excreted into the bile and consequently intestine either directly or indirectly after conversion into bile acids. High levels of HDL are associated with a decreased risk of atherosclerosis and coronary heart disease.

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ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

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关键词：Human High Density Lipoprotein，【HDL】人高密度脂蛋白，HDL