【比伐鲁定】人比伐卢定/【比伐鲁定】人比伐卢定/【比伐鲁定】

产品名称：

产品货号：pro-357

产品规格：1

应用类型：The active of Bivalirudin substance is a synthetic 20 amino acid peptide. The amino acid sequence is Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly- Asn-Gly-Asp-Phe-Glu-Glu-Ile- Pro-Glu-Glu-Tyr-Leu. The Mw is 2180 dalton.

保存建议：Lyophilized Bivalirudin although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Bivalirudin should be stored at 4℃ between 2-7 days and for future use below -18℃.For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.Please prevent freeze-thaw cycles.

背景资料：Bivalirudin directly inhibits thrombin by specifically binding as well to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Bivalirudin is a specific and reversible direct thrombin inhibitor.Thrombin， which is a serine protease， plays a central role in the thrombotic process； it cleaves fibrinogen into fibrin monomers and activates Factor XIII to Factor XIIIa， allowing fibrin to develop a covalently cross-linked structure which stabilizes the thrombus. Thrombin also activates Factors V and VIII， which promotes further thrombin generation， activates platelets， stimulating aggregation and granule release.

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关键词：Human Bivalirudin ，【比伐鲁定】人比伐卢定，Bivalirudin