MDM2抗体MDM2兔多抗抗体Ubiquitin prote
in ligase E3 Mdm2 antibody抗体MDM2 Antibody, FITC conjugated抗体- ￥880 - 1320
- CUSABIO
- CN
- CSB-PA11628C0Rb
- 2025年07月15日
- /
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Peptide sequence from Human E3 ubiquitin-protein ligase Mdm2 protein (374-391AA)
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
FITC
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
Q00987
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
/
- 浓度：
>95%,Protein G purified
- 靶点：
MDM2
- 抗体英文名：
MDM2 Antibody, FITC conjugated
- 抗体名：
Ubiquitin protein ligase E3 Mdm2 antibody
- 规格：
100μl/50μl
| 规格： | 100μl | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 50μl | 产品价格： | ￥880.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
功能
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity).风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验-SNAP时，如果雷帕霉素存在，FRB和FKBP之间就会发生特异性相互作用；如果雷帕霉素缺失，FRB与FKBP只能发生较弱的相互作用（图6）。 （2）MDM2-p53相互作用——低亲和力 肿瘤蛋白MDM2是一种E3泛素连接酶，也是p53肿瘤抑制蛋白最重要的细胞拮抗剂。同时，它还是肿瘤药物研发中一个已被验证过的靶标。MDM2与p53结合，并通过蛋白酶促进p53降解。已有研究表明，抑制p53与MDM2的相互作用，可致使某些癌细胞死亡（图7）。 1.4.1.2 通过HTRF进行蛋白
Studies of the Ubiquitin Proteasome System
Protocol 10: Detection of E3 Activity in Immunoprecipitated Protein Alternate Protocol 5: Detection of Ubiquitin Modification of Substrates After GST Pull‐Down Detection of Ubiquitylation in Vivo Basic Protocol 11: Lysis and Immunoprecipitation
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