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- 2025年07月08日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
WEE1-IN-3
- 库存：
10
- 供应商：
TargetMol
- CAS号：
2272976-28-8
- 规格：
1 mL/100 mg/5 mg/50 mg/1 mg/25 mg/10 mg
| 规格： | 1 mL | 产品价格： | ￥3280.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥13200.0 |
| 规格： | 5 mg | 产品价格： | ￥3130.0 |
| 规格： | 50 mg | 产品价格： | ￥9830.0 |
| 规格： | 1 mg | 产品价格： | ￥1320.0 |
| 规格： | 25 mg | 产品价格： | ￥7290.0 |
| 规格： | 10 mg | 产品价格： | ￥4590.0 |
Product Introduction
Bioactivity
英文名:WEE1-IN-3
描述:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
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文献和实验the activity of the cyclin dependent kinase cdc2 as cells prepare to enter mitosis. Cdc2 activity is further regulated by phosphorylation of its tyrosine-15 residue by the kinase wee1. Phosphorylation of tyrosine-15 inhibits cdc2 activity
Methods to Study Cancer Therapeutic Drugs That Target Cell Cycle Checkpoints
are activated in response to diverse DNA-damaging agents and radiation, thus representing a critical barrier limiting therapeutic efficacy. To date, despite efforts to target other components of checkpoint signaling pathways (e.g., ATM, Chk2, Wee1), checkpoint
Measurement of Wee Kinase Activity
The Wee kinases (Wee1, Wee2, and Myt1) are major regulators of mitotic entry. They function by phosphorylating Cdc2 and related Cdks on conserved tyrosine and threonine residues. This phosphorylation blocks the activity of the Cdc
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