ALL1-Fused Gene From Chromosom

产品名称：ALL1-Fused Gene From Chromosome 9 Protein (MLLT3) Antibody-ALL1-Fused Gene From Chromosome 9 Protein (MLLT3) Antibody

产品货号：abx032719

产品规格：80ul#400ul

应用类型：WB

保存建议：ALL1-Fused Gene From Chromosome 9 Protein (MLLT3) Antibody-ALL1-Fused Gene From Chromosome 9 Protein (MLLT3) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t (9;11) (p22;q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified; BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.

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关键词：ALL1-Fused Gene From Chromosome 9 Protein (MLLT3) Antibody，ALL1-Fused Gene From Chromosome 9 Protein (MLLT3) Antibody，待更新