Sialic Acid Binding Ig Like Le

产品名称：Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody-Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody

产品货号：abx028723

产品规格：80ul#400ul

应用类型：WB, IHC

保存建议：Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody-Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100 to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.

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关键词：Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody，Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody，待更新