Pre-mRNA 3'-End-Processing Fac

产品名称：Pre-mRNA 3'-End-Processing Factor FIP1 (FIP1L1) Antibody-Pre-mRNA 3'-End-Processing Factor FIP1 (FIP1L1) Antibody

产品货号：abx005389

产品规格：20ul#50ul#100ul#200ul

应用类型：WB, IHC, IF/ICC

保存建议：Pre-mRNA 3'-End-Processing Factor FIP1 (FIP1L1) Antibody-Pre-mRNA 3'-End-Processing Factor FIP1 (FIP1L1) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：FIP1L1 Antibody is a Rabbit Polyclonal antibody against FIP1L1. This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

点击：Pre-mRNA 3'-End-Processing Factor FIP1 (FIP1L1) Antibody-Pre-mRNA 3'-End-Processing Factor FIP1 (FIP1L1) Antibody查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询Abbexa中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品网站。

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关键词：Pre-mRNA 3'-End-Processing Factor FIP1 (FIP1L1) Antibody，Pre-mRNA 3'-End-Processing Factor FIP1 (FIP1L1) Antibody，待更新