FGF Receptor 1 (pY653) Antibod

产品名称：FGF Receptor 1 (pY653) Antibody-FGF Receptor 1 (pY653) Antibody

产品货号：abx000121

产品规格：20ul#50ul#100ul#200ul

应用类型：WB

保存建议：FGF Receptor 1 (pY653) Antibody-FGF Receptor 1 (pY653) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：FGF Receptor 1 (pY653) Antibody is a Rabbit Polyclonal antibody against FGF Receptor 1 (pY653). The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

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关键词：FGF Receptor 1 (pY653) Antibody，FGF Receptor 1 (pY653) Antibody，待更新