p44 / 42 MAPK (Erk1 / 2) Antib

产品名称：p44 / 42 MAPK (Erk1 / 2) Antibody-p44 / 42 MAPK (Erk1 / 2) Antibody

产品货号：abx011157

产品规格：100ul

应用类型：ELISA, WB, IHC, FCM

保存建议：p44 / 42 MAPK (Erk1 / 2) Antibody-p44 / 42 MAPK (Erk1 / 2) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors such as U0126 and PD98059.

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关键词：p44 / 42 MAPK (Erk1 / 2) Antibody，p44 / 42 MAPK (Erk1 / 2) Antibody，待更新