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- 文献和实验
- 技术资料
- 保存条件：
常温
- 库存：
现货
- 供应商：
联硕生物
- CAS号：
11097-48-6
- 规格：
1瓶
一般描述
Human proinsulin, the single-chain peptide precursor of insulin, consists of the insulin A and B chains connected by the 31 amino acid C-peptide. Cleavage of proinsulin by proteolytic enzymes produces insulin and free C-peptide. The product here is the 35-mer peptide (Arg−Arg-C-Peptide-Lys-Arg) observed to separate the insulin A and B chains.[1]
生化/生理作用
C-Peptide Fragment (55-89) is a fragment derived from the proinsulin C-peptide. C-peptide has cell signaling activity that involves calcium-dependent intracellular signaling. C-Peptide Fragment 55-89 may be used to help researchers understand the role of specific sequences within the C-peptide in binding, conformation and function of C-peptide.
C-Peptide was initially thought to have no intrinsic biological activity. More recent research has identified multiple biological effects of C-peptide, including binding to cell membranes, activation of signaling pathways, and stimulation of Na+,K+-ATPase and endothelial nitric oxide synthetase.[2][3][4] However, the exact function of C-peptide is unclear due to conflicting physiological effects.
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文献和实验Proinsulin C-peptide prevents type-1 diabetes-induced decrease of renal Na+-K+-ATPase α1-subunit in rats.
Nordquist L, Shimada K, et al.
Diabetes and Metabolism, 26, 193-199 (2010)
为连接肽（ conneting peptide）之简写。系从胰岛素原（ proinsulin）产生胰岛素时所形成的多肽。
On the Discovery of Precursor Processing
of 30–35 amino acids and terminated with the A chain. Paired basic residues were identified at the sites of excision of the C-peptide. Human proinsulin and C-peptide were then similarly obtained and sequenced. The human C-peptide assay was developed
Assessment of Insulin Secretion in the Mouse
, proinsulin. Insulin and C-peptide are produced when endopeptidases, prohormone convertases 2 and 3 (PC2 and PC3, respectively), cleave proinsulin at two paired basic amino acid sites, Lys 64 -Arg 65 and Arg 31 -Arg 32 (
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