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- 详细信息
- 文献和实验
- 技术资料
- 库存：
10
- 供应商：
广东固康生物科技有限公司
- 检测范围：
——
- 检测方法：
酶联免疫法
- 应用：
——
- 适应物种：
人
- 标记物：
——
- 样本：
血清/血浆
- 规格：
96人份（复孔检测样本：40个）/盒
【产品名称】
通用名称：阿狄科®钙卫蛋白检测试剂盒（酶联免疫法）
英文名称：IDK® Calprotectin (MRP 8/14) (Serum, Plasma)
【包装规格】
规格：96人份（复孔检测样本：40个）/盒
测试次数：96（40份样本一式两份）
【预期用途】
用于测定血清和血浆中的钙卫蛋白 (MRP 8/14,S100A8/A9)。仅用于体外诊断。
【背景知识】
钙卫蛋白的替代名称：MRP8/14,L1,(p8,14), p34,S100 A8/A9
异复合钙卫蛋白的两种蛋白质的替代名称：
. S100A8,Calgranulin A,MRP8(迁移抑制因子相关蛋白8),CP-10(小鼠)
. S100A9,Calgranulin B,MRP14(Migration inhibitory factor-related protein-14) 钙卫蛋白是一种钙结合蛋白，主要由中性粒细胞和单核细胞分泌。钙卫蛋白是一种异质复合物，由两者组成 S100 家族-属于蛋白质 S100A8（钙颗粒蛋白 A，MRP 8）和 S100A9（钙颗粒蛋白 B，MRP 14）。 S100A8 和 S100A9 在上皮组织中的表达首先与人类和小鼠的鳞状上皮细胞和伤口愈合有关。 
参考文献：
1. Striz,l.&Trebichavsky,Il.Calprotectin - a pleiotropic molecule in acute and chro-nic inflammation. Physiological research / Academia Scientiarum Bohemoslovaca53,245-53(2004).
2. Yui, S., Nakatani, Y.& Mikami, M. Calprotectin (S100A8/S10OA9), an inflammatory protein complex from neutrophils with a broad apoptosis-inducing activity.Bio-logical & pharmaceutical bulletin 26,753-60(2003).
3. Odink, K. et al.Two calcium-binding proteins in iniltrate macrophages of rheu-matoid arthritis.Nature 330,80-2(1987).
4. Wilkinson, M. M. et al. Expression pattern of two related cystic fibrosis-associatedcalcium-binding proteins in normal and abnormal tissues.Journal of cell science91 ( Pt 2), 221-30 (1988).
5. Müller, F.， Froland, S. S., Aukrust, P.& Fagerhol,M. K. Elevated serum calprotectin levels in HIV-infected patients: the calprotectin response during ZDV treatment isassociated with clinical events. Journal of acquired immune deficiency syndromes7,931-9 (1994).
6. Hermani,A. et al.Calcium-binding proteins S100A8 and S100A9 as novel diagnos-tic markers in human prostate cancer.Clinical cancer research: an officialjournalofthe American Association for Cancer Research 11,5146-52(2005).
7. Heller, F.， Frischmann, S.,Grünbaum,M., Zidek, W. & Westhoff, T. H. Urinary cal-protectin and the distinction between prerenal and intrinsic acute kidney injury.Clinical journal of the American Society of Nephrology : CJASN 6,2347-55(2011).
8. Lonnkvist, M. H., Theodorsson, E., Holst, M., Ljung,T.& Hellstrom, P.M.Blood che-mistry markers for evaluation of inflammatory activity in Crohn's disease duringinfliximab therapy. Scandinavian journal of gastroenterology 46,420-7(2011).
9. Borekci,B.,Aksoy,H,Oztürk,N. & Kadanali, S.Correlation between Calprotectinand Oxidized LDL in Preeclampsia.Turkish Journal of Medical Sciences 39,191-195(2009). 
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文献和实验1. Striz,l.&Trebichavsky,Il.Calprotectin - a pleiotropic molecule in acute and chro-nic inflammation. Physiological research / Academia Scientiarum Bohemoslovaca53,245-53(2004).
2. Yui, S., Nakatani, Y.& Mikami, M. Calprotectin (S100A8/S10OA9), an inflammatory protein complex from neutrophils with a broad apoptosis-inducing activity.Bio-logical & pharmaceutical bulletin 26,753-60(2003).
3. Odink, K. et al.Two calcium-binding proteins in iniltrate macrophages of rheu-matoid arthritis.Nature 330,80-2(1987).
4. Wilkinson, M. M. et al. Expression pattern of two related cystic fibrosis-associatedcalcium-binding proteins in normal and abnormal tissues.Journal of cell science91 ( Pt 2), 221-30 (1988).
5. Müller, F.， Froland, S. S., Aukrust, P.& Fagerhol,M. K. Elevated serum calprotectin levels in HIV-infected patients: the calprotectin response during ZDV treatment isassociated with clinical events. Journal of acquired immune deficiency syndromes7,931-9 (1994).
6. Hermani,A. et al.Calcium-binding proteins S100A8 and S100A9 as novel diagnos-tic markers in human prostate cancer.Clinical cancer research: an officialjournalofthe American Association for Cancer Research 11,5146-52(2005).
7. Heller, F.， Frischmann, S.,Grünbaum,M., Zidek, W. & Westhoff, T. H. Urinary cal-protectin and the distinction between prerenal and intrinsic acute kidney injury.Clinical journal of the American Society of Nephrology : CJASN 6,2347-55(2011).
8. Lonnkvist, M. H., Theodorsson, E., Holst, M., Ljung,T.& Hellstrom, P.M.Blood che-mistry markers for evaluation of inflammatory activity in Crohn's disease duringinfliximab therapy. Scandinavian journal of gastroenterology 46,420-7(2011).
9. Borekci,B.,Aksoy,H,Oztürk,N. & Kadanali, S.Correlation between Calprotectinand Oxidized LDL in Preeclampsia.Turkish Journal of Medical Sciences 39,191-195(2009).
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