- ￥726 - 3183
- TargetMol
- 美国
- T23028
- 2025年07月08日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
MRT67307 HCl (1190378-57-4 free base)
- 库存：
10
- 供应商：
TargetMol
- CAS号：
T23028
- 规格：
1 mL/50 mg/10 mg/5 mg
| 规格： | 1 mL | 产品价格： | ￥753.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥3183.0 |
| 规格： | 10 mg | 产品价格： | ￥1266.0 |
| 规格： | 5 mg | 产品价格： | ￥726.0 |
Product Introduction
Bioactivity
英文名:MRT67307 HCl (1190378-57-4 free base)
描述:MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.
SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and other anti-inflammatory molecules. IKKε and TBK-1 mediate the phosphorylation of interferon regulatory factor 3 (IRF3). MARK1 is a Serine/threonine-protein kinase.
In macrophages, MRT67307 prevented the production of IFNβ and the phosphorylation of IRF3 without suppressing the activation of NF-κB, which showed that MRT67307 blocked the induction of Pellino 1 through inhibiting TBK1/IKKε kinase activity [1] [3]. Also, MRT67307 completely blocked the TBK1- or IKKε-induced decrease in the mobility of Pellino 1 [3]. Exposed macrophages to MRT67307 increased the levels of the anti-inflammatory cytokines IL-1ra and IL-10 and decreased the levels of proinflammatory cytokines (such as IL-6, IL-12, and TNF) in response to bacterial lipopolysaccharide (LPS) [4].
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文献和实验实验57 核酸的测定 Ⅰ．方法一 原理 核酸在生物体内，尤其是在蛋白质合成方面具有重要的意义。通过对不同年龄植物的各组织内核酸含量的测定，能进一步加深对核酸生理功能的理解。 用过氯酸沉淀植物组织匀浆中的核蛋白，用醇醚除去其中的脂类后，以稀碱水解然后酸化，在低温条件下使RNA与DNA分离，制成RNA和DNA提取液，再根据核酸中碱基对紫外线的吸收，测定核酸的含量
Ribonuclease A (RNase A), DNase-free
FeatureThe RNase A is free of DNase activity. It is not necessary to heat it before use.DescriptionThe Ribonuclease A (RNase A) is an endoribonuclease that specifically degrades single-stranded RNA at C and U residues. It cleaves the phosphodiester
Protein Syntheses in Cell Free Systems
Materials •Suspension culture of fibroblast cells (1 liter)•35 mM Tris-HCl,pH 7.4,140 mM NaCl (TBS buffer)•10 mM Tris-HCl,pH 7.5,10 mM KCl,and 1.5 mM magnesium acetate (TBS-M)•10X TBS-M200 mM Tris-HCl,pH 7.5,1200 mM KCl,50 mM magnesium acetateand 70
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