Merck Millipore特约代理商|AB19015 A

Production and Characterization of Anti-Cocaine Catalytic Antibodies

(1 ,2 ), but the elevated concentration of antibody required for binding and neutralizing cocaine blood levels is still a problem to be overcome. This hurdle is less difficult for a catalytic antibody, which not only binds, but also destroys what it binds to.

Assessment of Gelatinases (MMP-2 and MMP-9 by Gelatin Zymography

are multidomain proteases that contain a zinc atom in the active site and are produced in a latent inactive form (zymogen) (2 ). Acquisition of enzymatic activity requires cleavage of the inhibitory N-terminal domain (3 ). Thus, generation of the active form

Generation of Antibody Molecules Through Antibody Engineering

been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional