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文献和实验The discovery of two isoforms of the cyclooxygenase (COX) enzyme, COX-1 and COX-2, has provided the rationale for development of selective COX-2 inhibitors as a class of safer drugs for the treatment of pain, symptoms of osteoarthritis
Photodynamic therapy (PDT) using the photosensitizer Photofrin is approved for the clinical treatment of solid tumors. PDT causes cytotoxic oxidative stress, but additionally induces prosurvival molecules such as cyclooxygenase-2 (COX
Quantitative Analysis of Cyclooxygenase Metabolites of Arachidonic Acid
, catalyzed insertion of oxygen occurs enzymatically via action of one of the two known cyclooxygenase isoenzymes (COX-1 and COX-2). The unstable bicyclic intermediate, PGH 2 , undergoes subsequent metabolism to form prostaglandins (PG), thromboxane
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