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文献和实验Hereditary Breast and Ovarian Cancer Genes
, in part due to difficulty in early diagnosis of the disease. Most cases of breast or ovarian cancer appear to occur without a clear family history of the disease. These sporadic cases account for approximately 95% of all breast cancer. Possibly, low-penetrance genes
Epigenetic Markers of Early Tumor Development
have been considered one of the most promising tools for the early diagnosis of cancer. Some of these epigenetic alterations including promoter hypermethylation of genes like P16INK4a , BRCA1 , BRCA2 , ERα and RARβ2 , APC , and RASSF1A have been associated with early
The breast cancer 1 and 2 , early onset (BRCA1 and BRCA2 ) genes are important for double-strand break repair by homologous recombination. Cells with inactivating mutations of the BRCA1 or BRCA2 tumor suppressor genes show increased
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