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Beyond Rhodopsin: G Protein-Coupled Receptor Structure and Modeling Incorporating the 2-adrenergic and Adenosine A2A Crystal Structures

For quite some time, the majority of GPCR models have been based on a single template structure: dark-adapted bovine rhodopsin. The recent solution of β2AR, β1AR and adenosine A2A receptor crystal structures has dramatically expanded the GPCR

Characterization of P1 (Adenosine) Purinoceptors

adenosine (ADO) is an important modulator of cellular function in mammalian tissues, modulating cellular function and neuronal excitability via interactions with different cell surface receptor subtypes that are heterogeneously distributed

Detection of Receptor Heteromers Involving Dopamine Receptors by the Sequential BRET-FRET Technology

to be identified. In SRET experiments, the oxidation of a Renilla Luciferase substrate triggers acceptor excitation by BRET and subsequent energy transfer to a FRET acceptor. Using this methodology here we describe the heteromerization between adenosine A2A