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文献和实验In an effort to produce renm mhibttory peptides, the preparation of (2 S ,4 S ,5 S )-5-( t -Butoxycarbonylamino)-4-( t -butyldimethylsilyloxy)-2-isopropyl-7-methyl octanotc acid, 15 , was carried out ( 1 ). This pseudo-dipeptide was used
The release of arachidonic acid (AA) from membrane phospholipids by phospholipase A2 (PLA2 ) is a critical step in the generation of lipid mediators by mast cells. AA released by PLA2 activity is metabolized to bioactive compounds
. Proline is the only cyclic amino acid. It is nonpolar and shares many properties with the aliphatic group. Basic amino acids are polar and positively charged at pH values below their pKa's, and are very hydrophilic. Even though the basic amino acids
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