goldbio特约代理商|S-140-50 Spectino

A High‐Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14

can be selectively inhibited by targeting the catalytic site with drug?like compounds. Notably, the mammalian 26S proteasome is associated with three major DUBs: RPN11, UCH37, and USP14. Because the ubiquitin ?chain?trimming? activity of USP14 can inhibit proteasome