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文献和实验Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-β1
growth factor-β1 - F-actin - cytoskeleton remodeling Introduction The phenomenon of plasticity of differentiated adult cells could have a great therapeutic potential, but at the same time, it is characteristic of progression
between the ECMand the actin cytoskeleton. The small GTPase, Rac, induces the formation ofsmall adhesions at the leading edge (5–7). These adhesions serve as traction points and transmit strong propulsive forces that move the cell body forward(8). The maturation
) e R.C. Parker, Methods of Tissue Culture , 3rd ed., p. 57, Harper, New York, 1961 f G.O. Gey and M.K. Hey, Am J. Cancer, 27 , 55 (1936) g
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