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文献和实验Design and Generation of Gene‐Targeting Vectors
., Mabuchi, I., Yamamoto, T., and Aizawa, S. 1990. Homologous recombination at c‐fyn locus of mouse embryonic stem cells with use of diphtheria toxin A‐fragment gene in negative selection. Proc. Natl. Acad. Sci. U.S.A. 87:9918‐9922
Genetic and Pharmacologic Models for Type 1 Diabetes
with aldehyde fuchsin (blue color). Note the beta cell degranulation (loss of staining) in mutant mice of both sexes. At the time of necropsy, both mutant mice were hyperglycemic. At later ages, islets from severely hyperglycemic males are almost completely
Alternate Protocol 1: Measurement of Dynamic Protein‐Protein Interactions by BRET: Example Of β‐Arrestin2 Recruitment to Agonist‐Activated GPCRs as a Functional Readout of Receptor Activation Reagents and Solutions
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