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文献和实验The fusion protein toxins that have been described are generally composed of the catalytic and transmembrane domains of a bacterial toxin (e.g., diphtheria toxin [DT] or Pseudomonas exotoxin A) to which a polypeptide hormone, growth factor
Genetic Detoxification of Bacterial Toxins
Several pathogens, such as Corynebacterium diphtheriae, Clostridium tetani, Bordetella pertussis, Vibrio cholerae , enterotoxigenic Escherichia co1i (1 ), and even some emerging pathogens, such as Helicobacter pylori (2 ), produce potent
In Vivo Depletion of FoxP3+ Tregs Using the DEREG Mouse Model
specific depletion of Treg by application of diphtheria toxin at any desired point of time during an ongoing immune response. This chapter will elaborate the advantages and disadvantages of employing different genetic approaches and discuss
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