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Current Status of Clinical Islet Cell Transplantation

Clinical outcomes of pancreas transplantation were superior to that of islet transplantation until the introduction of the Edmonton protocol. Significant advances in islet isolation and purification technology, novel immunosuppression

Islet-Derived Progenitors as a Source of In Vitro Islet Regeneration

Current therapies do not prevent the complications of diabetes. Furthermore, these therapies do not address the underlying pathology; the lack of functional β-cell mass that occurs in both types 1 and 2 diabetes. While pancreas and islet

Transplantation Models to Characterize the Mechanisms of Stem Cell–Induced Islet Regeneration

these distinct cell types. Importantly, these cell types can be transplanted into immunodeficient mice rendered beta?cell deficient by streptozotocin (STZ) treatment, in order monitor functional recovery from hyperglycemia and to characterize endogenous islet