K107231P Anti-CASP1 Polyclonal

【抗体靶点简介】

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

【实验操作视频参考】

Western blot实验参考操作流程

Immunohistochemistry实验参考操作流程

抗体在科研领域应用十分广泛，对解析生物学过程、探究疾病发病机制、创新药物研发与临床治疗研究均起到关键支撑作用。

索莱宝现有30000余种经过严格实验验证的抗体产品，全面覆盖神经科学、细胞凋亡、表观遗传学等热门研究方向，适配 WB、IHC、ELISA、IP、co-IP 等主流实验技术场景。包括内参标签抗体，以及多种标记类型的一抗、二抗，充分满足客户多样化实验选型需求。索莱宝拥有成熟专业的抗体制备与质量检测平台，从免疫制备、纯化提纯到实验验证全流程严格筛选评估，全方位保障每一支抗体的性能与品质。

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