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Human PD-1/PD-L1 Checkpoint Pathway qPCR Array is designed to facilitate gene expression profiling of 88 key genes involved in human PD-1/PD-L1 checkpoint pathway, and to help identifying potential prognostic biomarkers for cancer immunotherapy. PD-1/PD-L1 checkpoint pathway plays an important role in the maintenance of T cell stability, as well as mediating inhibitory signals for proliferation and function of T effector cells. PD-1/PD-L1 immune checkpoint blockade has resulted in enhancement of T cell immunity against tumors and viral pathogens. Brief examples of how genes may be grouped according to their functions are shown below:
Co-stimulatory/inhibitory receptors: PDCD1 (PD-1), CD28, CD27, CD276, ICOS, TNFRSF18, TNFRSF4, TNFRSF9
Co-stimulatory/inhibitory pathway: CD274 (PD-L1), PDCD1LG2 (PD-L2), CD4, LCK, CD2, CD247, CSK, PTPN11, PTPN2, PTPN6, NCOR2
PD-L1 induction: IFNG, IL15, IL17A, IL2, IL21, IL7, MAPK1, NRP1, STAT3
T cell receptor signaling: AKT1, CD3, CTLA4, CD8, GSK3B, JUN, NFKB1, PDPK1
T cell function regulation: BATF, FOXO1, KRAS, MAPK8, MTOR, NFATC1, PI3Ks, SKP2, TLR9
B cell function regulation: CD80, CD86, POU2F2
Proinflammatory molecules: CSF2, IL4, IL10, IRF6, TNF, VEGFA
Additional immune checkpoint genes:HAVCR2, HNF1A, LAG3, TIGIT
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文献和实验Abrogation of the RB-p16Tumor Suppressor Pathway in Human Lung Cancer
There is compelling evidence that human lung cancers are characterized by disruption of several important physiological pathways that govern proliferation, apoptosis, intracellular signaling, and cell-cell interactions. Uncontrolled cellular
%。我的天敌很可怕，但是我也不是吃素的。Statista 2016年的一份统计报告预测了2020年全球十大抗癌药。看到没，这些都是我家族成员。 数据来源于www.statista.com 由于我家族成员众多，对付敌人的方式各不相同。我就给大家选择性的介绍一下吧。PD-1/PD-L1最近比较有名气，市场对它激烈程度无法想象，其市场峰值高达350亿美元。默沙东（Merck）、百时美施贵宝（BMS）、阿斯利康（AZN）、罗氏（Roche）均在火速推进各自的临床项目。唉呀妈呀
Assay (Invitrogen) as suggested by Illumina. Illumina Bead Array MicroRNA Detection Starting with 500 ng/sample of total RNA, mature microRNAs were amplified with the Illumina human v1 MicroRNA expression profiling kit containing primers for 743
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