Thrombopoietin; 10 μg

Thrombopoietin

Chemicon (Millipore)

TPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. Chemicon's Human TPO is a soluble 18.5 kDa protein containing 174 amino acid residues which comprises the receptor binding domain of the Mpl-ligand protein.

Cell Culture

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Human

Hematopoietic Stem Cells

• Maintenance & Expansion
• Differentiation
• General Cell Culture

E.coli

Lyophilized protein from 5mM Tris, pH 7.6, with no additives.

The lyophilized powder, though stable at room temperature, is best stored at -20°C. Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.5-1.0 mg/mL. This solution can be diluted into other aqueous buffers and stored at 4ºC for 1 week or -20ºC for future use. Reconstituted TPO should be stored in working aliquots at -20°C.

The ED50 was determined by the dose-dependent stimulation of the proliferation of M07e cells is <=1.0 ng/mL, corresponding to a specific activity of >=1x10(e6) units/mg.

Cytokines & Growth Factors

• THPO
• TPO
• MGC163194
• MPLLG
• thrombopoietin
• MGDF
• ML
• MKCSF

Cytokines & Growth Factors

TPO

Greater than 98% by SDS-PAGE and HPLC analyses. . Endotoxin level is less than 0.1 ng per mg (1 EU/μg) of human TPO.