Immortalized Mouse Schwann Cel

Schwann cells are valuable tools for diabetic neuropathy pathogenesis involving glycation, reduced regenerative capability, oxidative stress, and other neurodegenerative diseases. The Immortalised Mouse Schwann Cells express glial cell markers (S100, GFAP, p75NTR); transcription factors involved in Schwann cell development and peripheral myelin formation (Krox20, Oct6, PAX3, and SOX10); and neurotrophic factors (NGF, BDNF, GDNF, and CNTF). In the presence of growth factors, such as PDGF-BB, aFGF, bFGF, or TGF-β1, these cells exhibit mitogenic reponses. The IMS32 cells may be used to study action mechanisms involved in peripheral nerve regeneration, and as an in vitro model to assess the pathogenesis of neurological diseases.雪旺细胞是糖尿病神经病变发病机制的宝贵工具，包括糖基化、再生能力降低、氧化应激和其他神经退行性疾病。永生化小鼠雪旺细胞表达胶质细胞标志物(S100, GFAP, p75NTR);参与雪旺细胞发育和周围髓鞘形成的转录因子(Krox20、Oct6、PAX3和SOX10);以及神经营养因子(NGF、BDNF、GDNF和CNTF)。在生长因子如PDGF-BB、aFGF、bFGF或TGF- 1存在的情况下，这些细胞表现出有丝分裂反应。IMS32细胞可用于研究外周神经再生的作用机制，并可作为评估神经系统疾病发病机制的体外模型。