- ￥992
- Sigma-Aldrich
- 进口
- V4629-1G
- 2026年04月02日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温
- 保质期：
根据瓶身LOT号查询
- 英文名：
(±)-Verapamil hydrochloride
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
152-11-4
- 规格：
1G
属性
产品名称
（±）-维拉帕米 盐酸盐, ≥99% (titration), powder
Quality Level
100
assay
≥99% (titration)
form
powder
color
white
mp
142 °C (dec.) (lit.)
solubility
methanol: 50 mg/mL, ethanol: soluble
SMILES string
Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InChI
1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChI key
DOQPXTMNIUCOSY-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
说明
Application
- 抑制受精卵中的钙振荡
- 阻断钙通道，从而阻断 IL-1β（白细胞介素-1β）的作用，导致膜去极化
- 研究维拉帕米对 1，3-二亚油酰甘油（DLG）细胞毒性的影响
Biochem/physiol Actions
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验An Acromegaly Disease Zebrafish Model Reveals Decline in Body Stem Cell Number along with Signs of Premature Aging.
In our previous publication, it was shown that growth hormone (GH) excess in acromegaly affects the cell integrity of somatic cells through increased DNA damage throughout the body and impaired DNA repair pathways. Acromegaly is a hormone disorder pathological condition that develops as a result of growth hormone over-secretion from the pituitary gland. We produced a zebrafish acromegaly model to gain a better understanding of the excess GH effects at the cellular level. Here we show that the acromegaly zebrafish model progressively reduced the number of stem cells in different organs and increased oxidative stress in stem cells. Importantly, the decline in the stem cells was even more apparent than in aged fish. The controversy and debate over the use of GH as an anti-aging therapy have been going on for several years. In this study, excess GH induced aging signs such as increased senescence-associated (SA)-β-galactosidase staining of abdominal skin and similarity of the pattern of gene expression between aged and acromegaly zebrafish. Thus, this study highlights the role of excess GH in acromegaly stem cells.
progenitor cells can be seeded onto titanium slides for 15 minutes and adhere under physiological (arterial) shear forces of 15 dynes/cm2 . As shown in Figure 10, EPCs spread under the influence of flow from 210 ± 11.4 μm2 , immediately after seeding
Replication timing by density transfer
-Aldrich (previously from Isotec, which is now part of Sigma-Aldrich) "-N" medium =1.61 g yeast nitrogen base w/o amino acids and ammonium sulfate, 11.1 g succinic acid, 6.67 g NaOH per litre. Pronase : We use
提取，NSB 含有 1% ( V/V ) Nonidet NP-40 (Roche) 和 0.5% ( V/V ) 脱氧胆酸钠（Sigma) 。 ( 2 ) 可溶性馏分（S2 ) (图 8-1，S2 )：第二份馏分用低离子强度缓冲液提取，这种缓冲液含有 10 mmol/L Tris-HCl ( pH 8.0 ) 和 1 mmol/L EDTA。 ( 3 ) 染色质馏分（图 8-1， Chr)：为了提取第三份馏分，使用的缓冲液由 NSB 组成 ，其中含有 100 μg/ml 无
技术资料暂无技术资料 索取技术资料
