SIGMA 239658-50G 2,2-双(4-羟基苯基)

Bisphenols are the environmental pollution of a highly harmful, but different in their magnitude, influence on the living organisms. Among various aspects of the toxicity of these compounds their effect on the red blood cells is intensively investigated. The aim of this work was to compare the effect of bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) on model erythrocyte membranes and to get insight into the origin of the differences in the harmful effect of these substances on cells. Thus, the influence of bisphenols on multicomponent Langmuir films imitating the outer leaflet of erythrocyte membrane was thoroughly analyzed. An important step of the experiments were the studies on the effect of bisphenols on the films composed from particular erythrocyte membrane lipids. It was confirmed that both BPA and BPF affect model lipid systems more strongly than BPS, by changing their condensation, ordering, stability and morphology. However, the most essential conclusion was that BPA acts on the erythrocyte lipids more selectively than BPS and BPF and the influence exerted by this molecule is more strongly determined by the membrane composition. It was also suggested that cholesterol may act as the molecule of a decisive role from the point of view of the magnitude of the incorporation and the effect of BPA and BPF on membrane. Thus, the level of bisphenols toxicity to erythrocytes may depend on the concentration of cholesterol in their membranes.