- ￥275
- Sigma-Aldrich
- 进口
- SML2262-10MG
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
Ramelteon
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
196597-26-9
- 规格：
10MG
属性
表单
powder
旋光性
[α]/D -50 to -60°, c = 1.0 in chloroform-d
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CCC(NCC[C@H]1C(C(CCO2)=C2C=C3)=C3CC1)=O
InChI
1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m0/s1
InChI key
YLXDSYKOBKBWJQ-LBPRGKRZSA-N
基因信息
human ... MTNR1A(4543) , MTNR1B(4544)
生化/生理作用
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文献和实验Ramelteon ameliorated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway.
Parkinson's disease (PD) is a common neurodegenerative disease with global health and economic impact. 1-methyl-4-phenylpyridinium (MPP+)-induced mitochondrial dysfunction and oxidative stress are reported to participate in the pathological mechanism of PD. Ramelteon is a novel oral hypnotic agent that has recently been reported to display neuronal protective effects. However, it is unknown whether Ramelteon possesses a beneficial effect in PD. In this study, we aimed to examine the potential function of Ramelteon in MPP+-challenged neurons. We found that Ramelteon rescued the cell viability reduced by MPP+-stimulation. Further, oxidative stress in MPP+-challenged SH-SY5Y cells was mitigated by Ramelteon as verified by the upregulated levels of mitochondrial reactive oxygen species (ROS) and protein carboxyl, and the upregulation of NADPH oxidase 4 (NOX-4). Furthermore, the declined mitochondrial membrane potential (ΔΨm) caused by MPP+ was reversed by Ramelteon. Importantly, Ramelteon attenuated MPP+-induced apoptosis, accompanied by a decreased ratio of Bax/Bcl-2, inhibition of cytochrome C release, and downregulation of cleaved caspase-3. For the first time, we conclude that Ramelteon might ameliorate MPP+-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway.
实验26 兔的消化、呼吸和泄殖系统 一、目的 通过对兔消化、呼吸和泄殖系统的观察，了解哺乳类有关系统的主要特征；掌握解剖哺乳类的基本技术 二、内容 （一）实验用兔的处死方法。 （二）兔的消化、呼吸和泄殖系统的解剖和观察。 三、实验材料与用具 活的家兔（或大白鼠）。 解剖器、解剖盘、骨剪、10mL注射器及针头、棉花等。 四、实验操作及观察
提取样品的总RNA后，一般根据RNA的凝胶电泳图来判断RNA的质量。由于RNA容易形成二级结构，因此常用甲醛变性胶来进行RNA电泳，得到的电泳图能真实反映RNA的质量状况。一、试剂：DEPC（Sigma公司产品），MOPs（Bocherigmer公司产品），甲酰胺（Formamide，Sigma公司产品），溴酚蓝（Bromphenol Blue，Sigma公司产品）。EDTA-Na2，氢氧化钠，醋酸钠，甲醛，甘油，分析纯，国产。二、试剂配制：1、DEPC 水的处理：用量筒量取去离子水2L
PRODUCTION OF COMPLETELY ES CELL-DERIVED FETUSES BY AGGREGATION WITH TETRAPLOID
of aggregation plate Materials: Dissecting microscope; Sterile tissue culture dishes (Easy Grip 35 x 10 mm, Falcon 3001-3); 1 ml syringe with 26 G 1/2 needle of KSOM medium; light mineral oil (EMBRYO TESTED) (e.g. Sigma: M8410);
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