- ￥3380
- TargetMol
- 美国
- TP1956
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
PKC ζ pseudosubstrate
- 库存：
10
- 供应商：
TargetMol
- CAS号：
TP1956
- 规格：
1 mg
Product Introduction
Bioactivity
英文名:PKC ζ pseudosubstrate
描述:Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.
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文献和实验三七家园 呵呵，希望大侠们，大牛们，前辈们不吝赐教。。。。:P licanming 可以讲具体一点吗？ 三七家园 谢谢楼上的关心，我现在要检测pkc三个亚基δ,ε,ζ在用0.2uM的PMA（pkc的激动剂）后如何被激活？（是被磷酸化呢？还是蛋白量表达增加？或者别的什么？）怎样检测这种激活？（如果是前两个，我想用western blot因为我现在只会这个技术） ffyy
Protein Kinase C: Measurement of Translocation, Activation, and Role in Cellular Responses
PKC (nPKC) enzymes (δ, ɛ,ζ, η,and θ) are Ca2+ -independent, whereas members of the atypical PKCs (aPKC), ζ and λ, lack the binding site for DAG. Phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), also bind to and activate those enzyme
Compartmentalized Protein Kinase C Activation in Ovarian Carcinoma Cells
or novel (n) PKC: δ, ε, η, θ, and �, and Group C or atypical (a) PKC: ζ and λ (ι) (1 ,3 ,4 ). Whereas cPKCs require Ca2+ and diacylglycerol (DAG) phorbol esters for their activities, nPKCs and aPKCs are Ca2+ -independent. aPKCs are also insensitive
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