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- T14367
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
AZ1495
- 库存：
10
- 供应商：
TargetMol
- CAS号：
2196204-23-4
- 规格：
10 mg/1 mg/25 mg/50 mg/100 mg/5 mg/1 mL
| 规格： | 10 mg | 产品价格： | ￥3720.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1070.0 |
| 规格： | 25 mg | 产品价格： | ￥5880.0 |
| 规格： | 50 mg | 产品价格： | ￥8290.0 |
| 规格： | 100 mg | 产品价格： | ￥10900.0 |
| 规格： | 5 mg | 产品价格： | ￥2470.0 |
| 规格： | 1 mL | 产品价格： | ￥2720.0 |
Product Introduction
Bioactivity
英文名:AZ1495
描述:AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).
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文献和实验,Gregory B,Hover A,Chen MY,Luci J,Joo SJ,Handwerker D,Liang J,Boyd R,Hunicke- Smith S,Simpson ZB,Caven T, Sochat V,Shine JM,Gordon E,Snyder AZ,Adeyemo B,Petersen SE,Glahn D, McKay DR,Curran JE,Göring HHH,Carless MA,Blangero J,Frick L,Marcotte E, Mumford JA
Protocols for Studying Antizyme Expression and Function
Antizyme (AZ) is a key molecule in feedback regulation of cellular polyamines. It is induced by polyamines through stimulation of ribosomal frameshifting during its translation. In mammals, AZ is diverged into three paralogs, AZ1–3. Tissue
Identification, Assay, and Functional Analysis of the Antizyme Inhibitor Family
essential cellular functions, their intracellular concentration is tightly regulated via a unique autoregulatory circuit that responds to the intracellular concentration of polyamines. In the heart of this circuit is a small protein called antizyme (Az
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