Deoxycholic Acid (sodium salt

次级胆汁酸；浓度为0.2%v/v时可抑制七种艰难梭菌菌株中TCA诱导的孢子萌发；浓度为0.02%v/v时可抑制艰难梭菌培养上清液对Vero细胞的生长并降低其细胞毒性；浓度为200µM时可抑制使用HCT116细胞的报告检测中电离辐射诱导的p53依赖性转录；与正常饮食喂养的大鼠相比，高脂饮食诱发的肥胖大鼠模型中其粪便和肠道组织水平升高；已发现结直肠癌患者的血清水平升高。A secondary bile acid; inhibits TCA-induced spore germination in seven C. difficile strains at 0.2% v/v; inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells at 0.02% v/v; inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells at 200 µM; fecal and intestinal tissue levels are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet; increased serum levels have been found in patients with colorectal cancer.