Myrothecine A

一种单端孢霉烯毒素，可抑制A549、MCF-7、HepG2和SMMC-7721癌细胞的增殖（IC50分别为95、70、60和25µM）；诱导HepG2细胞中G1细胞周期停滞，同时增加Bax和裂解caspase-3、-5和-8水平，并在50µM浓度下诱导SMMC-7721细胞凋亡。A trichothecene mycotoxin; inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells (IC50s = 95, 70, 60, and 25 µM, respectively); induces G1 cell cycle arrest in HepG2 cells, as well as increases Bax and cleaved caspase-3, -5, and -8 levels and induces apoptosis in SMMC-7721 cells at 50 µM.