Chlamydocin

一种HDAC抑制剂；对HDAC1的选择性优于HDAC6（IC50分别为0.15和1,100nM）；在1-1,000nM时可增加A2780细胞中组蛋白H3和组蛋白H4的乙酰化；抑制A2780、Malme-3M、MCF-7、HT-29和HeLa癌细胞的生长（IC50分别为0.36、45、5.3、4.3和14nM）；在20-160mg/kg时可使P185小鼠同种异体移植模型中的寿命延长10%。A HDAC inhibitor; selective for HDAC1 over HDAC6 (IC50s = 0.15 and 1,100 nM, respectively); increases acetylation of histone H3 and histone H4 in A2780 cells at 1-1,000 nM; inhibits growth of A2780, Malme-3M, MCF-7, HT-29, and HeLa cancer cells (IC50s = 0.36, 45, 5.3, 4.3, and 14 nM, respectively); increases lifespan by 10% in a P185 mouse allograft model at 20-160 mg/kg.