MRX-2843

Mer和FLT3抑制剂（IC50分别为1.3和1nM）；抑制Axl和Tyro3（IC50分别为15和17nM）；抑制MOLM-14和MV4-11AML细胞中的Mer磷酸化（10-300nM）；减少Kasumi-1AML细胞的克隆扩增（IC50=143.5nM）；分别以65和50mg/kg的剂量增加NOMO-1和MOLM-14AML小鼠异种移植模型中的存活率。A Mer and FLT3 inhibitor (IC50s = 1.3 and 1 nM, respectively); inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively); inhibits Mer phosphorylation in MOLM-14 and MV4-11 AML cells from 10-300 nM; reduces clonal expansion of Kasumi-1 AML cells (IC50 = 143.5 nM); increases survival in a NOMO-1 and MOLM-14 AML mouse xenograft models at 65 and 50 mg/kg, respectively.