Decursinol angelate

一种具有多种生物活性的吡喃香豆素；抑制各种癌细胞系的生长（ED50s=24-56μM）；降低雌激素刺激的MCF-7乳腺癌细胞的生长；激活从大鼠脑中纯化的PKC；选择性地抑制犬肝微粒体中CYP1A1/2而不是CYP2D15和CYP3A12（Kis分别为67.56、872.5和853.9μM）；降低Aβ25-35诱导的细胞毒性和MDA生成并增加PC12细胞中的SOD和GPx活性；在甩尾和热板试验中具有抗伤害活性，并在200mg/kg剂量下减少小鼠乙酸诱导的翻滚。A pyranocoumarin with diverse biological activities; inhibits the growth of various cancer cell lines (ED50s = 24-56 μM); decreases estrogen-stimulated growth of MCF-7 breast cancer cells; activates PKC purified from rat brain; selectively inhibits CYP1A1/2 over CYP2D15 and CYP3A12 in canine liver microsomes (Kis = 67.56, 872.5, and 853.9 μM, respectively); reduces Aβ25-35-induced cytotoxicity and MDA production and increases SOD and GPx activities in PC12 cells; has antinociceptive activity in the tail flick and hot plate tests and reduces acetic acid-induced writhing in mice at 200 mg/kg .