Lonicerin

一种具有多种生物活性的类黄酮；抑制黄嘌呤氧化酶（IC50=37.4µg/ml）并清除DPPH羟基和超氧化物自由基（IC50s分别为9.2、236.8和143.9µg/ml）；以1和2mg/kg隔天三次剂量给药，可减轻白色念珠菌细胞壁和弗氏佐剂诱发的完全性关节炎小鼠模型中的爪水肿；以20和40µg/ml剂量给药，可降低体外NO生成和T细胞增殖；对大鼠原代皮质神经元中谷氨酸诱发的神经毒性具有神经保护作用。A flavonoid with diverse biological activities; inhibits xanthine oxidase (IC50 = 37.4 µg/ml) and scavenges DPPH hydroxy, and superoxide radicals (IC50s = 9.2, 236.8, and 143.9 µg/ml, respectively); reduces paw edema in a mouse model of C. albicans cell wall- and complete Freund's adjuvant-induced arthritis at 1 and 2 mg/kg three times every other day; decreases NO production and T cell proliferation in vitro at 20 and 40 µg/ml; neuroprotective against glutamate-induced neurotoxicity in rat primary cortical neurons.